Hypothetical Midlife Lifestyle Interventions and Dementia Risk in US Older Adults: A Comparative Effectiveness Microsimulation Study
Roch A Nianogo, Nicola A Churchill, Deborah E Barnes · 2025
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Description
Roch Nianogo, Nicola Churchill, and Deborah Barnes use a 2025 computer model to test what mid-life habit changes could do to dementia risk. Single habit fixes often fall short, since risk has many roots. The team drew on survey data for more than twelve thousand adults. They modeled exercise, quitting smoking, and stronger social support, alone and combined. They also compared aiming at high-risk people with aiming at everyone.
Exercise alone cut the modeled risk of dementia by a clear margin. Social support and quitting smoking alone showed smaller, less certain cuts. All three combined cut risk by about a third in the broad approach. The gain was smaller when the same mix was aimed only at high-risk people. The model suggests broad, combined action in mid-life could pay off most. It is a test of what-if cases, not a trial in real people.
Catalog record
| CREATOR | Roch A Nianogo, Nicola A Churchill, Deborah E Barnes |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |