Multi‐omics analysis of neuron‐derived small extracellular vesicles to identify novel peripheral biomarker of cognitive impairment in individuals with type 2 diabetes
Ashish Kumar, Jacob Alexander Cleary, Yixin Su, Sangeeta Singh, Marjorie Howard, Kathleen M. Hayden, Jingyun Lee, Cristina M Furdui, Mark A. Espeland, Jingzhong Ding, Gagan Deep · 2025
Read Multi‐omics analysis of neuron‐derived small extracellular vesicles to identify novel peripheral biomarker of cognitive impairment in individuals with type 2 diabetes by Ashish Kumar, Jacob Alexander Cleary, Yixin Su, Sangeeta Singh, Marjorie Howard, Kathleen M. Hayden, Jingyun Lee, Cristina M Furdui, Mark A. Espeland, Jingzhong Ding, Gagan Deep (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714642.txt.
Description
Ashish Kumar and co-authors report a biomarker study, published in 2025, on memory problems in people with type two diabetes. Brain tissue cannot be sampled in living patients, so the team turned to tiny vesicles released by nerve cells into the blood. These small packets carry RNA and proteins that may reflect what is happening inside the brain.
Samples came from fifty-six adults with diabetes, half with normal thinking and half with probable dementia. The team read the vesicles with RNA sequencing and protein measurement, a combined approach known as multi-omics. Their results point to candidate markers tied to insulin resistance in the brain, which could one day support blood tests for early memory decline.
Catalog record
| CREATOR | Ashish Kumar, Jacob Alexander Cleary, Yixin Su, Sangeeta Singh, Marjorie Howard, Kathleen M. Hayden, Jingyun Lee, Cristina M Furdui, Mark A. Espeland, Jingzhong Ding, Gagan Deep |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |