Dynamic and static functional network connectivity distinguish symptomatic and non‐symptomatic individuals with CADASIL
Henry J Bockholt, Jane S Paulsen, Bradley T Baker, Helen Petropoulos, Arvind Caprihan, Kevin M. Johnson, Michael D Geschwind, Laura B. Eisenmenger, David S Liebeskind, Jordan Clemsen, Nicholas Pasley, William H. Adams, Michael A Newton, Vince D Calhoun · 2025
Read Dynamic and static functional network connectivity distinguish symptomatic and non‐symptomatic individuals with CADASIL by Henry J Bockholt, Jane S Paulsen, Bradley T Baker, Helen Petropoulos, Arvind Caprihan, Kevin M. Johnson, Michael D Geschwind, Laura B. Eisenmenger, David S Liebeskind, Jordan Clemsen, Nicholas Pasley, William H. Adams, Michael A Newton, Vince D Calhoun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714635.txt.
Description
Henry Bockholt and co-authors show that brain network patterns separate people with CADASIL who have symptoms from those who do not, in a 2025 study. CADASIL is an inherited disease of small brain arteries. It is a key model for how vessel damage disrupts brain communication. Strokes and dementia follow in many patients.
More than two hundred participants joined longitudinal assessments despite pandemic hurdles. Resting brain scans yielded static and dynamic network measures. Symptomatic and quiet carriers differed on both kinds of measure. Network change may precede or mirror clinical decline. Such markers could stage the disease without waiting for strokes. Trial designers gain endpoints that move faster than disability. Families carrying the gene get a research window into their future.
Catalog record
| CREATOR | Henry J Bockholt, Jane S Paulsen, Bradley T Baker, Helen Petropoulos, Arvind Caprihan, Kevin M. Johnson, Michael D Geschwind, Laura B. Eisenmenger, David S Liebeskind, Jordan Clemsen, Nicholas Pasley, William H. Adams, Michael A Newton, Vince D Calhoun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |