Plasma Biomarkers Predict Cognitive Decline in Alzheimer's Disease
Núria Guillén, Jordi Sarto, Diana Esteller, Iria Perales, Jose Ríos‐Guillermo, Josep Maria Augé, Laura Naranjo, Raquel Ruiz‐García, Jordi Juncà‐Parella, Adrià Tort‐Merino, Guadalupe Fernandez‐Villullas, Ainoa Alberique, Yolanda González, Anna Antonell, Sergi Borrego‐Écija, Magdalena Castellví, Bea B · 2025
Read Plasma Biomarkers Predict Cognitive Decline in Alzheimer's Disease by Núria Guillén, Jordi Sarto, Diana Esteller, Iria Perales, Jose Ríos‐Guillermo, Josep Maria Augé, Laura Naranjo, Raquel Ruiz‐García, Jordi Juncà‐Parella, Adrià Tort‐Merino, Guadalupe Fernandez‐Villullas, Ainoa Alberique, Yolanda González, Anna Antonell, Sergi Borrego‐Écija, Magdalena Castellví, Bea B (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714613.txt.
Description
Núria Guillén and co-authors test whether blood markers forecast thinking decline in Alzheimer's disease in a 2025 study. Spinal fluid and blood markers already help diagnose the disease. Whether they also predict how fast a mind will fade was unsettled.
The team followed 139 people with biologically confirmed disease, testing memory and thinking yearly for up to five years. Two blood markers stood out: patients starting with higher levels of a tau fragment and a glial protein lost ground faster on a standard mental test. A nerve damage marker in blood, and all spinal fluid markers, showed no such link. The authors say simple blood tests may help doctors and families plan, and trials pick patients likelier to decline.
Catalog record
| CREATOR | Núria Guillén, Jordi Sarto, Diana Esteller, Iria Perales, Jose Ríos‐Guillermo, Josep Maria Augé, Laura Naranjo, Raquel Ruiz‐García, Jordi Juncà‐Parella, Adrià Tort‐Merino, Guadalupe Fernandez‐Villullas, Ainoa Alberique, Yolanda González, Anna Antonell, Sergi Borrego‐Écija, Magdalena Castellví, Bea B |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |