Mapping Anatomical Boundaries from Histology to Antemortem MRI to Inform Automatic Segmentation of Medial Temporal Lobe Subregions
Amanda E Denning, Sydney A Lim, Yue Li, Niyousha Sadeghpour, Sadhana Ravikumar, Ranjit Ittyerah, Eunice Chung, Madigan Bedard, Karthik Prabhakaran, Winifred Trotman, Alejandra Bahena, Daniel T Ohm, John L Robinson, Theresa Schuck, Dylan M Tisdall, Emilio Artacho‐Perula, Maria Mercedes Iniguez de Onz · 2025
Read Mapping Anatomical Boundaries from Histology to Antemortem MRI to Inform Automatic Segmentation of Medial Temporal Lobe Subregions by Amanda E Denning, Sydney A Lim, Yue Li, Niyousha Sadeghpour, Sadhana Ravikumar, Ranjit Ittyerah, Eunice Chung, Madigan Bedard, Karthik Prabhakaran, Winifred Trotman, Alejandra Bahena, Daniel T Ohm, John L Robinson, Theresa Schuck, Dylan M Tisdall, Emilio Artacho‐Perula, Maria Mercedes Iniguez de Onz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714609.txt.
Description
Amanda Denning and co-authors present a neuroanatomy report, published in 2025, grounding brain scan maps of memory regions in real tissue. The medial temporal lobe, where Alzheimer's disease takes hold early, has intricate subregions that scans usually divide crudely. The team assembled a rare dataset from seventeen brain donors linking fine microscope anatomy, postmortem scans, and scans taken during life.
Expert anatomists annotated the boundaries by hand across serial tissue sections. Those annotations train and test an automatic tool that outlines the subregions on ordinary scans. The authors describe the effort as the most complete attempt so far to anchor scan based markers of Alzheimer's in true anatomy, a step toward measuring early disease change with confidence.
Catalog record
| CREATOR | Amanda E Denning, Sydney A Lim, Yue Li, Niyousha Sadeghpour, Sadhana Ravikumar, Ranjit Ittyerah, Eunice Chung, Madigan Bedard, Karthik Prabhakaran, Winifred Trotman, Alejandra Bahena, Daniel T Ohm, John L Robinson, Theresa Schuck, Dylan M Tisdall, Emilio Artacho‐Perula, Maria Mercedes Iniguez de Onz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |