Modeling tau spreading in Alzheimer’s disease in the AD workbench environment
Nicolai Franzmeier, Michael Schöll · 2025
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Description
Nicolai Franzmeier and Michael Schöll showed in 2025 how a cloud workspace can rerun a complex study of Alzheimer's disease. The study models how the tau protein spreads through linked brain areas over time. Work of this kind often stays locked in expert labs, where few others can check or reuse it.
Using data from a large imaging project, the pair joined rest scans with tau scans taken over time. They reran the work inside the Alzheimer's Disease Workbench, a shared cloud space with Python and R tools. The rerun matched the first results: linked areas gained tau together, and tau spread outward from local start points. Shared data and code let other teams repeat and extend the work with ease.
Catalog record
| CREATOR | Nicolai Franzmeier, Michael Schöll |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |