Characterizing the effects of calcineurin/NFAT inhibitor treatment on gray and white matter microstructure in the beagle model of Alzheimer's disease
Jessica A Noche, Hamsanandini Radhakrishnan, Margo F Ubele, Kathy Boaz, Jennifer L Mefford, Erin D Jones, Jessica A Perpich, Beverly Meacham, Jeffrey Smiley, Stasia A Bembenek Bailey, Laszlo G Puskas, David K Powell, Lorena Sordo, Michael J Phelan, Christopher M Norris, Elizabeth Head, Craig EL Star · 2025
Read Characterizing the effects of calcineurin/NFAT inhibitor treatment on gray and white matter microstructure in the beagle model of Alzheimer's disease by Jessica A Noche, Hamsanandini Radhakrishnan, Margo F Ubele, Kathy Boaz, Jennifer L Mefford, Erin D Jones, Jessica A Perpich, Beverly Meacham, Jeffrey Smiley, Stasia A Bembenek Bailey, Laszlo G Puskas, David K Powell, Lorena Sordo, Michael J Phelan, Christopher M Norris, Elizabeth Head, Craig EL Star (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714586.txt.
Description
Jessica Noche and co-authors present a 2025 study in beagle dogs on two drugs and the aging brain. Dogs develop brain changes much like those in Alzheimer's disease as they age. Too much of a protein called calcineurin has been linked to cell death and swelling in the brain. Blocking it, or a signal path below it, might slow that harm. Forty-three dogs were split among a dummy pill and the two drugs.
Brain scans were taken each year over four years of treatment. The scans tracked the fine structure of both gray and white matter in key areas. Most areas changed only a small amount with age in all groups. A few changes appeared in just one drug group or the other. The study gives a close record of how these drugs act on the aging dog brain. That record can guide later work in people.
Catalog record
| CREATOR | Jessica A Noche, Hamsanandini Radhakrishnan, Margo F Ubele, Kathy Boaz, Jennifer L Mefford, Erin D Jones, Jessica A Perpich, Beverly Meacham, Jeffrey Smiley, Stasia A Bembenek Bailey, Laszlo G Puskas, David K Powell, Lorena Sordo, Michael J Phelan, Christopher M Norris, Elizabeth Head, Craig EL Star |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |