Combining plasma biomarkers for β‐amyloid diagnosis and cognitive prognosis across the clinical spectrum: normal, amnestic, and non‐amnestic
Katheryn A Q Cousins, Jeffrey S Phillips, Sandhitsu R Das, Kyra O’Brien, Thomas F Tropea, Alice Chen‐Plotkin, Leslie M Shaw, Ilya M Nasrallah, Dawn Mechanic‐Hamilton, Corey T McMillan, David J Irwin, Eddie B Lee, David A Wolk · 2025
Read Combining plasma biomarkers for β‐amyloid diagnosis and cognitive prognosis across the clinical spectrum: normal, amnestic, and non‐amnestic by Katheryn A Q Cousins, Jeffrey S Phillips, Sandhitsu R Das, Kyra O’Brien, Thomas F Tropea, Alice Chen‐Plotkin, Leslie M Shaw, Ilya M Nasrallah, Dawn Mechanic‐Hamilton, Corey T McMillan, David J Irwin, Eddie B Lee, David A Wolk (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714563.txt.
Description
Katheryn Cousins and co-authors combine blood markers for Alzheimer's detection and forecast in a 2025 study. The disease shows as memory-led or other dementias, or hides in normal minds. Blood tests must work across that whole range. Three plasma markers are weighed alone and together.
Nearly six hundred participants had confirmed amyloid status. A third had normal cognition; the rest spanned mild impairment and both dementia styles. Combining markers improved amyloid detection over single tests. Accuracy differed by syndrome in the impaired group. Marker levels also predicted who declined faster, split by amyloid status. Panels, not single proteins, look like the practical path.
Catalog record
| CREATOR | Katheryn A Q Cousins, Jeffrey S Phillips, Sandhitsu R Das, Kyra O’Brien, Thomas F Tropea, Alice Chen‐Plotkin, Leslie M Shaw, Ilya M Nasrallah, Dawn Mechanic‐Hamilton, Corey T McMillan, David J Irwin, Eddie B Lee, David A Wolk |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |