Multimodal phenotyping of successful cognitive aging
Niklas Behrenbruch, Eóin N Molloy, Svenja Schwarck, Beate Schumann‐Werner, Berta Garcia‐Garcia, Niklas Vockert, Barbara Morgado, Michael Rullmann, Anne Hochkeppler, Larissa Fischer, Kathrin Baldauf, Peter Schulze, Patrick Müller, Andrew W Stephens, Marianne Patt, Andreas Schildan, Gusalija Behnisch, · 2025
Read Multimodal phenotyping of successful cognitive aging by Niklas Behrenbruch, Eóin N Molloy, Svenja Schwarck, Beate Schumann‐Werner, Berta Garcia‐Garcia, Niklas Vockert, Barbara Morgado, Michael Rullmann, Anne Hochkeppler, Larissa Fischer, Kathrin Baldauf, Peter Schulze, Patrick Müller, Andrew W Stephens, Marianne Patt, Andreas Schildan, Gusalija Behnisch, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714561.txt.
Description
Niklas Behrenbruch and a large team of co-authors profile successful cognitive aging in a 2025 paper. Some older adults keep memory as sharp as people decades younger, and the team asked what sets them apart. They combined brain scans, fitness tests, gene data, and surveys for more than one hundred sixty healthy adults over sixty.
The sharpest group, dubbed SuperAgers, had less white matter damage, a thicker key brain region, lower blood pressure, and less of a disease-linked protein in the temporal lobe than typical peers. Across the full sample, a younger cognitive age tied to thicker cortex, less of that protein, less anxiety, and somewhat stronger muscles. Fitness and gene traits mattered less than expected. The authors say brain health markers dominate the picture.
Catalog record
| CREATOR | Niklas Behrenbruch, Eóin N Molloy, Svenja Schwarck, Beate Schumann‐Werner, Berta Garcia‐Garcia, Niklas Vockert, Barbara Morgado, Michael Rullmann, Anne Hochkeppler, Larissa Fischer, Kathrin Baldauf, Peter Schulze, Patrick Müller, Andrew W Stephens, Marianne Patt, Andreas Schildan, Gusalija Behnisch, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |