Differential network‐based propagation of cortical thinning in atrophy subtypes in non‐demented individuals
Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Mara ten Kate, Giuseppe Pontillo, Isadora Lopes Alves, Mahnaz Shekari, Daniele Altomare, Anouk den Braber, Craig W Ritchie, Mercè Boada, Marta Marquié, Rik Vandenberghe, Emma S. Luckett, Bernard J Hanseeuw, Pieter Jelle Visser, Michael Schöll, Giova · 2025
Read Differential network‐based propagation of cortical thinning in atrophy subtypes in non‐demented individuals by Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Mara ten Kate, Giuseppe Pontillo, Isadora Lopes Alves, Mahnaz Shekari, Daniele Altomare, Anouk den Braber, Craig W Ritchie, Mercè Boada, Marta Marquié, Rik Vandenberghe, Emma S. Luckett, Bernard J Hanseeuw, Pieter Jelle Visser, Michael Schöll, Giova (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714505.txt.
Description
Luigi Lorenzini and co-authors sort people without dementia into brain shrinkage types and ask how each type spreads, in a 2025 conference paper. Shrinkage of the outer brain layer comes in more than one pattern once Alzheimer's disease is clear. Far less is known about these patterns in the early, silent stage.
The team used a European cohort of 1,323 adults, most with no amyloid in the brain and 229 with amyloid present. Brain scans gave the thickness of the outer layer in one hundred areas. A math method grouped people by their shrinkage pattern, and the team then checked how the groups differed in age, sex, gene risk, and amyloid load. Models also traced how shrinkage in linked areas may push spread over time.
Catalog record
| CREATOR | Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Mara ten Kate, Giuseppe Pontillo, Isadora Lopes Alves, Mahnaz Shekari, Daniele Altomare, Anouk den Braber, Craig W Ritchie, Mercè Boada, Marta Marquié, Rik Vandenberghe, Emma S. Luckett, Bernard J Hanseeuw, Pieter Jelle Visser, Michael Schöll, Giova |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |