Reduced plasma Aß42/40 in individuals with SCD predicts increasing plasma p‐Tau 181
Laura Göschel, Peter Koertvelyessy, Patty Hoede, Charlotte Teunissen, Agnes Flöel · 2025
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Description
Laura Goschel and co-authors published this study in two thousand twenty-five on early blood signs of Alzheimer's disease. A falling blood ratio of two amyloid forms is one of the first changes in the disease, and it shows up before thinking slips.
The team drew blood again and again over up to five years from healthy adults and from people who felt their memory slipping. They split the group into amyloid decliners and non-decliners by how the ratio moved. Among decliners, only the group with felt memory loss showed a steady yearly rise in a tau marker tied to disease advance. Self-report scores alone did not predict that rise. The authors say a felt sense of decline, paired with falling amyloid, marks people whose disease may be on the move.
Catalog record
| CREATOR | Laura Göschel, Peter Koertvelyessy, Patty Hoede, Charlotte Teunissen, Agnes Flöel |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |