Circulating metabolome in relation to cognitive impairment: a community‐based cohort of older adults
Yuhui Huang, Xuehui Sun, Qingxia Huang, Qiumin Huang, Xiao Chen, Xiaofeng Zhou, Hui Chen, Jie Shen, Mengyan Gao, Hui Zhang, Huiru Tang, Xiaofeng Wang, Xiaoyan Jiang, Yan Zheng, Changzheng Yuan · 2025
Read Circulating metabolome in relation to cognitive impairment: a community‐based cohort of older adults by Yuhui Huang, Xuehui Sun, Qingxia Huang, Qiumin Huang, Xiao Chen, Xiaofeng Zhou, Hui Chen, Jie Shen, Mengyan Gao, Hui Zhang, Huiru Tang, Xiaofeng Wang, Xiaoyan Jiang, Yan Zheng, Changzheng Yuan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714476.txt.
Description
Yuhui Huang and co-authors search blood chemistry for signs that flag fading memory and thinking in older adults. Their study draws on the Rugao Longevity and Ageing Study, a community cohort in China. Blood samples were read by nuclear magnetic resonance, and thinking was scored by two objective tests.
In a first stage with 1,643 people, the team found 28 metabolites tied to severely impaired thinking. A second stage followed new cases over two years, matched against healthy controls. Pathways linked to the flagged chemicals were mapped as well. Models built with the markers predicted new cases better than standard risk factors alone. The work hints that a blood test could one day help flag early decline.
Catalog record
| CREATOR | Yuhui Huang, Xuehui Sun, Qingxia Huang, Qiumin Huang, Xiao Chen, Xiaofeng Zhou, Hui Chen, Jie Shen, Mengyan Gao, Hui Zhang, Huiru Tang, Xiaofeng Wang, Xiaoyan Jiang, Yan Zheng, Changzheng Yuan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |