Anticholinergic burden and cognitive decline: findings from the ELSA‐Brasil cohort study
Adriana Nancy Medeiros dos Santos, Natalia G Gonçalves, Alessandra C Goulart, Maria Carmen Viana, Paulo A Lotufo, Isabela M Bensenor, Claudia Kimie Suemoto · 2025
Read Anticholinergic burden and cognitive decline: findings from the ELSA‐Brasil cohort study by Adriana Nancy Medeiros dos Santos, Natalia G Gonçalves, Alessandra C Goulart, Maria Carmen Viana, Paulo A Lotufo, Isabela M Bensenor, Claudia Kimie Suemoto (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714448.txt.
Description
Adriana dos Santos and six co-authors study whether drugs that block a brain chemical add up to harm thinking over time, in a 2025 conference paper. Many common drugs have this blocking effect, and the total load from all of them is called the anticholinergic burden. The team used a large health study of adults in Brazil.
More than thirteen thousand people were tested in three waves over eight years with memory and thinking tasks. A higher drug burden went with a faster fall in overall thinking scores. The fall was clearest in memory and in tasks that need planning and quick shifts. The authors say doctors should weigh this load when they hand out drugs to midlife and older adults.
Catalog record
| CREATOR | Adriana Nancy Medeiros dos Santos, Natalia G Gonçalves, Alessandra C Goulart, Maria Carmen Viana, Paulo A Lotufo, Isabela M Bensenor, Claudia Kimie Suemoto |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |