APOE4 moderates the association between cerebral small vessel disease and cortical tau accumulation in midlife
Liliana Espinoza, Matthew R Scott, Alexa S Beiser, Andy Q Banh, Vinu Philip, Saptaparni Ghosh, Emma G Thibault, Pauline Maillard, Charles Decarli, Georges El Fakhri, Keith A Johnson, Sudha Seshadri, Claudia L Satizabal · 2025
Read APOE4 moderates the association between cerebral small vessel disease and cortical tau accumulation in midlife by Liliana Espinoza, Matthew R Scott, Alexa S Beiser, Andy Q Banh, Vinu Philip, Saptaparni Ghosh, Emma G Thibault, Pauline Maillard, Charles Decarli, Georges El Fakhri, Keith A Johnson, Sudha Seshadri, Claudia L Satizabal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714429.txt.
Description
Espinoza and co-authors test in 2025 whether a gene risk for Alzheimer's disease changes how small vessel harm in the brain links to tau build up in midlife. Tau is a protein that clumps in the illness, and harm to tiny brain vessels may feed it. Carriers of one gene form face higher risk, so the interplay matters early.
The study drew on close to three hundred healthy adults in a long running heart study, with an average age in the mid fifties. Brain scans measured vessel harm and tau in three zones tied to memory. About a quarter carried the risk gene. Models weighed how the gene shifted the link.
Catalog record
| CREATOR | Liliana Espinoza, Matthew R Scott, Alexa S Beiser, Andy Q Banh, Vinu Philip, Saptaparni Ghosh, Emma G Thibault, Pauline Maillard, Charles Decarli, Georges El Fakhri, Keith A Johnson, Sudha Seshadri, Claudia L Satizabal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |