Advanced circadian rhythms in older adults are associated with higher amyloid‐β and tau PET burden and poorer short‐term memory
Joanna L Eckhardt, A Lisette Isenberg, Joy Stradford, Vahan Aslanyan, Laura E Fenton, Teresa Monreal, Judy Pa · 2025
Read Advanced circadian rhythms in older adults are associated with higher amyloid‐β and tau PET burden and poorer short‐term memory by Joanna L Eckhardt, A Lisette Isenberg, Joy Stradford, Vahan Aslanyan, Laura E Fenton, Teresa Monreal, Judy Pa (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714322.txt.
Description
Joanna Eckhardt and six co-authors link the timing of daily rest and activity rhythms to brain signs of Alzheimer's disease in a 2025 conference paper. The study covers 68 older adults, ages 55 to 80, who had early changes in thinking. Each wore a wrist motion sensor for about a month.
The team matched rhythm measures with brain scans for amyloid and tau, and with a short term memory test. People whose peak activity came early in the day had more amyloid and tau and scored worse on memory. Broken up rhythms also tracked with tau in key brain areas. Rhythm timing shifted with age, sex, and a gene risk form. The authors say daily timing may be an early sign worth watching.
Catalog record
| CREATOR | Joanna L Eckhardt, A Lisette Isenberg, Joy Stradford, Vahan Aslanyan, Laura E Fenton, Teresa Monreal, Judy Pa |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |