Plasma Biomarkers, Hippocampal Volume and Cognitive Effects of Oral ALZ‐801: The Phase 2 Biomarker Study and its Long‐Term Extension in APOE4 Carriers with Early Alzheimer’s Disease
Susan Abushakra, John A Hey, Kaj Blennow, Jakub Hort, Niels D Prins, Patrick Kesslak, Winnie Pak, Larry Shen, Xinyi Zhu, Caiyan Li, Adem Albayrak, Luc Bracoud, Joyce Suhy, Aidan Power, Martin Tolar · 2025
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Description
An oral drug called ALZ-801 aims to block the clumping of amyloid into the toxic clusters thought to drive Alzheimer's disease. Susan Abushakra and co-authors report a phase 2 study in 84 carriers of the APOE4 gene variant with early disease, all given the drug for two years, with a further two-year extension. Blood markers of the disease, brain scans, and memory tests tracked their progress.
After two years, a key blood marker of tau fell by about a third. The memory region of the brain shrank roughly a fifth less than in matched untreated people from a reference dataset. Memory scores held steady while the comparison group declined, and steadier memory tracked with less shrinkage. Nausea was the most common side effect, and it was mild.
Catalog record
| CREATOR | Susan Abushakra, John A Hey, Kaj Blennow, Jakub Hort, Niels D Prins, Patrick Kesslak, Winnie Pak, Larry Shen, Xinyi Zhu, Caiyan Li, Adem Albayrak, Luc Bracoud, Joyce Suhy, Aidan Power, Martin Tolar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |