Functional Connectivity and Longitudinal Changes in Amyloid Pathology in Cognitively Healthy Older Adults
Mara ten Kate, Luigi Lorenzini, Betty M Tijms, Alle Meije Wink, Elles Konijnenberg, Jori Tomassen, Sophie M van der Landen, Eco JC de Geus, Emma M Coomans, Lyduine E Collij, Philip Scheltens, Elsmarieke van de Giessen, Pieter Jelle Visser, Anouk den Braber, Frederik Barkhof · 2025
Read Functional Connectivity and Longitudinal Changes in Amyloid Pathology in Cognitively Healthy Older Adults by Mara ten Kate, Luigi Lorenzini, Betty M Tijms, Alle Meije Wink, Elles Konijnenberg, Jori Tomassen, Sophie M van der Landen, Eco JC de Geus, Emma M Coomans, Lyduine E Collij, Philip Scheltens, Elsmarieke van de Giessen, Pieter Jelle Visser, Anouk den Braber, Frederik Barkhof (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714247.txt.
Description
Mara ten Kate and fourteen co-authors test whether busy brain hubs gather amyloid faster in healthy older adults. Their 2025 study draws on a Dutch cohort of cognitively healthy monozygotic twins. Amyloid buildup is one of the first steps toward Alzheimer's disease, starting decades before symptoms, and active hub regions have been suspected as early targets.
Resting brain scans gave each of 100 regions a hub score based on its count of connections. PET scans measured amyloid at the start and again about 4.4 years later. The team checked whether hub scores forecast a shift to amyloid-positive status, and whether hubness tracks amyloid change region by region. Family ties between twins were handled in the statistics. The design speaks to whether brain wiring helps explain where the disease begins.
Catalog record
| CREATOR | Mara ten Kate, Luigi Lorenzini, Betty M Tijms, Alle Meije Wink, Elles Konijnenberg, Jori Tomassen, Sophie M van der Landen, Eco JC de Geus, Emma M Coomans, Lyduine E Collij, Philip Scheltens, Elsmarieke van de Giessen, Pieter Jelle Visser, Anouk den Braber, Frederik Barkhof |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |