Chemical chaperones mitigate chronic short sleep induced cognitive impairment
Kamalini Sengupta, Katya Scherbakova, Sydney Mason, Nirinjini Naidoo · 2025
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Description
Kamalini Sengupta and three co-authors test whether helper drugs can guard memory in mice kept on short sleep for weeks, in a 2025 conference paper. Poor sleep is tied to body illness, weak thinking, and higher risk of Alzheimer's disease. Lack of sleep strains the cell system that folds proteins, and long strain can harm memory.
Young adult mice had their sleep cut to eight hours a day, three days a week, for four weeks. Some got a helper drug that eases protein folding strain. Two weeks after the stint, all groups did alike on a place memory test. At five weeks, short sleep males without the drug did worse, while those on the drug did better. The authors say easing cell strain may shield memory from poor sleep.
Catalog record
| CREATOR | Kamalini Sengupta, Katya Scherbakova, Sydney Mason, Nirinjini Naidoo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |