Chalcone derivate as a promising candidate for treating Alzheimer’s disease
Murillo Orsatto Haas, Thaís C Ruaro, Grace Gosmann, Aline R. Zimmer · 2025
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Description
Alzheimer's disease attacks memory through plaques, tangles, inflammation, and oxidative damage all at once, so single-target drugs keep failing. Murillo Orsatto Haas and co-authors turned to chalcones, plant compounds with a record of calming several of those processes. They designed nineteen new variants and screened them in computer models and cell cultures.
Most variants looked drug-like and gentle on cells. One, called CHA 16, stood out. It shielded astroglial cells from oxidative attack, from excess glutamate, and from inflammatory insult. It also nourished the cells rather than merely sparing them. Computer checks suggested it could be swallowed and could cross into the brain. The authors nominate it for further testing.
Catalog record
| CREATOR | Murillo Orsatto Haas, Thaís C Ruaro, Grace Gosmann, Aline R. Zimmer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |