Unraveling Pathways in Alzheimer’s Disease: Insights into Rap1 Signaling Associations with Focal Adhesion and Shigellosis
Meher Garg, Inhan Lee · 2025
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Description
Standard Alzheimer's drugs aim at amyloid and tau, with modest success, so other pathways deserve a look. Meher Garg and Inhan Lee mine a public dataset of gene activity in a memory-related brain region from 46 patients and 32 controls. They search for pathways that run hot in the disease and might explain synaptic failure and cell damage.
Three pathways stood out: Rap1 signaling, focal adhesion, and, unexpectedly, the shigellosis pathway named for a gut infection. Five genes sat in both the Rap1 and shigellosis sets, and five others linked Rap1 to focal adhesion. The authors propose these shared genes and pathways as candidate markers and drug targets. They stress the findings need direct testing in future work. The analysis appears in 2025.
Catalog record
| CREATOR | Meher Garg, Inhan Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |