The Role of Sex in Post‐Mortem Neuropathology and Cognitive Decline
Rowan Dowd, Farooq Kamal, Mahsa Dadar, Michael Oliver, Cassandra Morrison · 2025
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Description
Dowd, Kamal, Dadar, Oliver, and Morrison study sex differences in brain pathology and cognitive decline in a 2025 paper. Women tend to show more Alzheimer's pathology and more symptoms at the same pathology level. The team used post-mortem data from a large aging cohort.
At death, women had higher tangle burden and higher disease staging than men. Amyloid and one vessel-related change did not differ by sex. For both sexes, more pathology meant faster decline before death. The link was stronger in women for every measure, even after matching for age and pathology level. Only women showed one added link to decline. The authors urge earlier action for women.
Catalog record
| CREATOR | Rowan Dowd, Farooq Kamal, Mahsa Dadar, Michael Oliver, Cassandra Morrison |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |