Supporting Participants in Preclinical Alzheimer’s Trials: Experience from a Research Participant Advisory Board and the A4 Study
Sarah Walter, Guadalupe Morales, Elizabeth Shaffer‐Bacareza, Jason Karlawish, Joshua D Grill, Michael C Donohue, Paula Cohen, Paul S S Aisen, Reisa A Sperling, The A4 Study Team · 2025
Read Supporting Participants in Preclinical Alzheimer’s Trials: Experience from a Research Participant Advisory Board and the A4 Study by Sarah Walter, Guadalupe Morales, Elizabeth Shaffer‐Bacareza, Jason Karlawish, Joshua D Grill, Michael C Donohue, Paula Cohen, Paul S S Aisen, Reisa A Sperling, The A4 Study Team (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714032.txt.
Description
Sarah Walter and a team that includes the A4 Study Team report 2025 lessons on supporting participants in preclinical Alzheimer's trials. Such trials can run for years and ask a lot of older adults, so the views of participants and their families matter for how trials are run.
Since 2020, a research participant advisory board has given input on pay, consent language, and how results are shared. A key call from the board is to let people choose to learn their own results, since many find them of deep personal worth. The paper also shares what was learned after top-line results from the A4 study came out.
Catalog record
| CREATOR | Sarah Walter, Guadalupe Morales, Elizabeth Shaffer‐Bacareza, Jason Karlawish, Joshua D Grill, Michael C Donohue, Paula Cohen, Paul S S Aisen, Reisa A Sperling, The A4 Study Team |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |