Comparison of [18F]MK6240 and [18F]Flortaucipir standardized uptake values (SUVs): the HEAD study
Cécile Tissot, Hsin‐Yeh Tsai, Dana Tudorascu, Firoza Z Lussier, Nesrine Rahmouni, Stijn Servaes, Joseph Therriault, Jenna Stevenson, Brian A Gordon, Belen Pascual, Val J Lowe, David N Soleimani‐Meigooni, Hwamee Oh, William E Klunk, Pedro Rosa‐Neto, William J Jagust, Tharick Ali Pascoal, Suzanne L Ba · 2025
Read Comparison of [18F]MK6240 and [18F]Flortaucipir standardized uptake values (SUVs): the HEAD study by Cécile Tissot, Hsin‐Yeh Tsai, Dana Tudorascu, Firoza Z Lussier, Nesrine Rahmouni, Stijn Servaes, Joseph Therriault, Jenna Stevenson, Brian A Gordon, Belen Pascual, Val J Lowe, David N Soleimani‐Meigooni, Hwamee Oh, William E Klunk, Pedro Rosa‐Neto, William J Jagust, Tharick Ali Pascoal, Suzanne L Ba (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714027.txt.
Description
Cécile Tissot and co-authors compared two tau PET tracers head to head in the same brains, in a 2025 study. Alzheimer's trials use either tracer to measure tau tangles, but their on- and off-target habits differ, blocking clean comparison across studies. Ninety participants received both scans, plus an amyloid scan, with readings taken in target and off-target regions against a cerebellar reference.
Every cross-tracer correlation came out significant. The team separated how much of the mismatch comes from the reference region itself. Links with age and amyloid status were also charted. Such maps help trials translate numbers between the field's two favorite tau dyes.
Catalog record
| CREATOR | Cécile Tissot, Hsin‐Yeh Tsai, Dana Tudorascu, Firoza Z Lussier, Nesrine Rahmouni, Stijn Servaes, Joseph Therriault, Jenna Stevenson, Brian A Gordon, Belen Pascual, Val J Lowe, David N Soleimani‐Meigooni, Hwamee Oh, William E Klunk, Pedro Rosa‐Neto, William J Jagust, Tharick Ali Pascoal, Suzanne L Ba |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |