GENETIC DELETION OF THE PRESINILIN‐LIKE PEPTIDASE SPPL2B SIGNIFICANTLY REDUCES NEUROINFLAMMATION AND HALTS PRODUCTION AND PLAQUE DEPOSITION IN PRE‐CLINICAL MODELS OF Alzheimer's DISEASE
Jack Badman, Gefei Chen, Sandra Pérez Garcia, Per Nilsson, Simone Tambaro · 2025
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Description
Jack Badman and four co-authors test whether removing a brain enzyme can slow Alzheimer's-like disease in mice in this 2025 paper. The enzyme, SPPL2b, cuts several proteins tied to the disease, including ones driving inflammation and amyloid production. It sits in memory regions of the brain.
In cultured neurons lacking the enzyme, a protective protein rose while soluble amyloid pieces fell sharply. In mice bred for amyloid disease, deleting the enzyme cut brain plaque deposits notably by four months of age. Brain inflammation in two regions also fell significantly. Cell work confirmed the protective protein grips the amyloid precursor more tightly without the enzyme. The authors nominate blocking this enzyme as a fresh treatment strategy.
Catalog record
| CREATOR | Jack Badman, Gefei Chen, Sandra Pérez Garcia, Per Nilsson, Simone Tambaro |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |