Cognitive impairment due to ischemic stroke in female rats is associated with secondary neurodegeneration, and attenuated with microRNA‐20a‐3p as assessed by diffusion tensor MR imaging and histological analysis
Dayalan Sampath, Jacob Singer, Balaji Gopalakrishnan, Zara Akbari, Monserrat Villarreal, David A Hurst, Brenda P Noarbe, Andre Obenaus, Farida Sohrabji · 2025
Read Cognitive impairment due to ischemic stroke in female rats is associated with secondary neurodegeneration, and attenuated with microRNA‐20a‐3p as assessed by diffusion tensor MR imaging and histological analysis by Dayalan Sampath, Jacob Singer, Balaji Gopalakrishnan, Zara Akbari, Monserrat Villarreal, David A Hurst, Brenda P Noarbe, Andre Obenaus, Farida Sohrabji (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714008.txt.
Description
Dayalan Sampath and co-authors test in a 2025 study a small RNA treatment against thinking loss after stroke in female rats. The RNA, mir20a-3p, guards brain cells acutely and softens long term decline in their past work. Decline after vessel disease ties to slow decay in cortex and limbic zones.
Middle aged females got a vessel blocking stroke beside the main brain artery. Treatment or a scrambled control went in at 4 hours, 24 hours, and 70 days. Thinking was probed to day 100 with fear and object memory tests. Postmortem scans measured white matter, ventricles, and water diffusion patterns in the brain. Tissue stains then checked the same decay story at cell level.
Catalog record
| CREATOR | Dayalan Sampath, Jacob Singer, Balaji Gopalakrishnan, Zara Akbari, Monserrat Villarreal, David A Hurst, Brenda P Noarbe, Andre Obenaus, Farida Sohrabji |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |