LXR Agonists as Therapeutic Agents for Myelin Repair: Exploring the Molecular Mechanisms of Oligodendrocyte Remyelination and Cholesterol Synthesis
Sampada P Tamhankar, Ian Steinke, Meenakshi Singh, Raj Amin · 2025
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Description
Sampada Tamhankar and three co-authors test whether drugs that switch on a fat control switch can help rebuild myelin in Alzheimer's disease, in a 2025 conference paper. Myelin is the fatty coat that speeds nerve signals, and it thins as the disease grows. The coat is rebuilt by cells called oligodendrocytes.
The switch, named LXR, steers cholesterol, a chief part of myelin. The team gave a strong switch on drug to mice bred for the disease and to a human cell line that acts like the coat building cells. Lab tests then read the cell proteins. Diseased mice showed lower levels of young and mature coat cells than normal mice. The work checks whether the drug can push those cells to recoat bare fibers.
Catalog record
| CREATOR | Sampada P Tamhankar, Ian Steinke, Meenakshi Singh, Raj Amin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |