Plasma ADRD biomarkers predict longitudinal declines in intra‐network functional brain connectivity, and baseline functional connectivity predicts longitudinal cognition
Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett A. Landman, Susan M. Resnick, Keenan A. Walker · 2025
Read Plasma ADRD biomarkers predict longitudinal declines in intra‐network functional brain connectivity, and baseline functional connectivity predicts longitudinal cognition by Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett A. Landman, Susan M. Resnick, Keenan A. Walker (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11714004.txt.
Description
Heather Dark and eight co-authors track how blood signs of brain disease link to slow shifts in how brain areas work together, in a 2025 conference paper. The data come from the Baltimore Longitudinal Study of Aging and cover adults who were thinking clearly. The team used rest scans that show which brain areas rise and fall in step.
Blood tests at the start measured amyloid, tau, and signs of nerve cell harm. Over time, some blood signs foretold a fade in links inside brain networks. Brain link strength at the start also foretold later thinking scores. The authors say the results help show how the disease may wear down brain networks years before clear loss shows.
Catalog record
| CREATOR | Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett A. Landman, Susan M. Resnick, Keenan A. Walker |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |