Large‐scale proteomic and genomic analysis identify plasma proteins influencing human brain structure and Alzheimer’s disease risk
Cyrus Ayubcha, Benjamin B Sun, Tian Ge, Chia‐Yen Chen · 2025
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Description
Cyrus Ayubcha and co-authors use genetics to ask which blood proteins actually shape the brain and Alzheimer's risk. Proteins can be measured by the thousands now, but correlation is not cause. The team ran Mendelian randomization, using gene variants as natural experiments, across the two largest plasma proteomics efforts, each over thirty thousand people.
Dozens of proteins tied to brain imaging measures survived the screen, on both tissue structure and white matter wiring. Colocalization checks then separated likely causal signals from genetic hitchhikers. One example stood out: blood progranulin moved both Alzheimer's risk and the volume of the caudate. The authors offer the shortlist as leads for mechanism studies and drug hunting.
Catalog record
| CREATOR | Cyrus Ayubcha, Benjamin B Sun, Tian Ge, Chia‐Yen Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |