Associations between tau accumulation and cognitive decline across the AD continuum differ by sex
Ellen Hanna Singleton, Niklas Mattsson‐Carlgren, Alexa Pichet Binette, Olof Strandberg, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson · 2025
Read Associations between tau accumulation and cognitive decline across the AD continuum differ by sex by Ellen Hanna Singleton, Niklas Mattsson‐Carlgren, Alexa Pichet Binette, Olof Strandberg, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713878.txt.
Description
Ellen Singleton and co-authors test whether sex changes how tau buildup tracks with mental decline. Tau is a protein that piles up in Alzheimer's disease. Women seem to gather tau faster yet hold up better for a time. The team followed a large Swedish group of amyloid positive adults with tau scans and thinking tests.
In people still thinking clearly, higher starting tau tied to odd patterns by sex across many brain zones. In impaired people, tau in some zones tied to faster decline. Split by tau load, women matched men's thinking paths at low and mid loads. The study adds nuance to how sex shapes disease course.
Catalog record
| CREATOR | Ellen Hanna Singleton, Niklas Mattsson‐Carlgren, Alexa Pichet Binette, Olof Strandberg, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |