Longitudinal changes in cerebral metabolic rate of oxygen in older adults without and with cognitive impairment
Jiani Wu, Kumiko Oishi, Anja Soldan, Corinne Pettigrew, Zixuan Lin, Yuxin Zhu, Dengrong Jiang, Xin Li, Abhay Moghekar, Peiying Liu, Kenichi Oishi, Marilyn S Albert, Hanzhang Lu · 2025
Read Longitudinal changes in cerebral metabolic rate of oxygen in older adults without and with cognitive impairment by Jiani Wu, Kumiko Oishi, Anja Soldan, Corinne Pettigrew, Zixuan Lin, Yuxin Zhu, Dengrong Jiang, Xin Li, Abhay Moghekar, Peiying Liu, Kenichi Oishi, Marilyn S Albert, Hanzhang Lu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713870.txt.
Description
How fast the aging brain burns oxygen is tracked over years in a 2025 study by Jiani Wu and co-authors. The measure, the cerebral metabolic rate of oxygen, sums up the brain's energy use, and its course through aging and early disease was poorly charted.
The data set is the largest of its kind: 526 measurements from 227 older adults in a long-running Baltimore cohort. Most stayed cognitively normal, a small group slid from normal to impairment during follow-up, and others began already impaired. Scans repeated over about three years used a noninvasive MRI method needing no injected tracers. The study maps how the brain's oxygen appetite changes with healthy aging and with decline.
Catalog record
| CREATOR | Jiani Wu, Kumiko Oishi, Anja Soldan, Corinne Pettigrew, Zixuan Lin, Yuxin Zhu, Dengrong Jiang, Xin Li, Abhay Moghekar, Peiying Liu, Kenichi Oishi, Marilyn S Albert, Hanzhang Lu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |