Relationship Between 18F‐AV‐1451 Binding in Human Brain and Tissue Alterations Defined by Quantitative Gradient Recalled Echo (qGRE) MRI Measurements
Satya V.V.N. Kothapalli, Tammie L.S. Benzinger, Brian A. Gordon, Cihat Eldeniz, Charles F Hildebolt, Manu S. Goyal, John C. Morris, Dmitriy A. Yablonskiy · 2025
Read Relationship Between 18F‐AV‐1451 Binding in Human Brain and Tissue Alterations Defined by Quantitative Gradient Recalled Echo (qGRE) MRI Measurements by Satya V.V.N. Kothapalli, Tammie L.S. Benzinger, Brian A. Gordon, Cihat Eldeniz, Charles F Hildebolt, Manu S. Goyal, John C. Morris, Dmitriy A. Yablonskiy (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713848.txt.
Description
Kothapalli and co-authors probe a tau scan tracer in Alzheimer research in a 2025 study. The tracer lights up tau tangles in the living brain, but it also sticks in iron-rich areas, which muddies readings. Sixty-eight older adults had both the tau scan and a special MRI that can tell tissue loss from iron buildup.
In memory regions, tracer levels rose with both early tissue loss signals and iron scores. Models that joined volume, iron, and loss measures predicted tracer uptake far better than volume alone. Readers learn that iron shapes tau scan results, a fact that matters for trial design and diagnosis.
Catalog record
| CREATOR | Satya V.V.N. Kothapalli, Tammie L.S. Benzinger, Brian A. Gordon, Cihat Eldeniz, Charles F Hildebolt, Manu S. Goyal, John C. Morris, Dmitriy A. Yablonskiy |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |