Impaired inactivation of the G protein‐coupled receptor Kinase 2 contributes to tau pathogenesis in human AD Neurons
Thais Rafael Guimaraes, Matthew L MacDonald, Amantha Thathiah · 2025
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Description
A signaling enzyme best known for switching off cell receptors may also feed the tau tangles of Alzheimer's disease. Thais Rafael Guimaraes and co-authors test that role in this 2025 study, using engineered cells, neurons grown from patients, and human brain tissue. Extra amounts of the enzyme, GRK2, raised tau's disease-linked phosphate tags at several known sites.
The enzyme binds tau directly, and the grip tightens in patient neurons. Brains from patients held less of the enzyme's off-switch form, which a partner pathway normally sets. Blocking the enzyme in patient neurons lowered tagged tau and eased oxidative stress. A form locked in the off state also protected cells. The authors propose the enzyme as a drug target with a clearer mechanism than past tau drugs.
Catalog record
| CREATOR | Thais Rafael Guimaraes, Matthew L MacDonald, Amantha Thathiah |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |