Operationalizing postmortem pathology‐MRI association studies in ADRD with MRI‐guided histology sampling: does closer proximity lead to stronger associations?
Chinmayee Athalye, Pulkit Khandelwal, Alejandra Bahena, Winifred Trotman, Daniel T Ohm, Sheina Emrani, Eric Teunissen‐Bermeo, Noah Capp, Sydney A Lim, Lisa M Levorse, Amanda E Denning, Ranjit Ittyerah, Theresa Schuck, Marianna Gabrielyan, Karthik Prabhakaran, Gabor Mizsei, John L Robinson, John A De · 2025
Read Operationalizing postmortem pathology‐MRI association studies in ADRD with MRI‐guided histology sampling: does closer proximity lead to stronger associations? by Chinmayee Athalye, Pulkit Khandelwal, Alejandra Bahena, Winifred Trotman, Daniel T Ohm, Sheina Emrani, Eric Teunissen‐Bermeo, Noah Capp, Sydney A Lim, Lisa M Levorse, Amanda E Denning, Ranjit Ittyerah, Theresa Schuck, Marianna Gabrielyan, Karthik Prabhakaran, Gabor Mizsei, John L Robinson, John A De (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713820.txt.
Description
Chinmayee Athalye and co-authors describe a 2025 method for linking brain scans to tissue samples after death. Studying donated brains is the surest way to confirm a dementia diagnosis. The team uses scan images to guide where tissue is cut, so each sample sits close to the spot the scan measured. They test whether closer sampling gives stronger links between scans and disease.
The work uses 29 brain halves from patients with Alzheimer's disease. Staff mark nineteen regions on high-detail scans, then print a mold of each brain to guide the cuts. Stains show tau protein in each sample, and software turns the stain into numbers. The setup could make scan-and-tissue studies more exact.
Catalog record
| CREATOR | Chinmayee Athalye, Pulkit Khandelwal, Alejandra Bahena, Winifred Trotman, Daniel T Ohm, Sheina Emrani, Eric Teunissen‐Bermeo, Noah Capp, Sydney A Lim, Lisa M Levorse, Amanda E Denning, Ranjit Ittyerah, Theresa Schuck, Marianna Gabrielyan, Karthik Prabhakaran, Gabor Mizsei, John L Robinson, John A De |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |