Short‐term Sirolimus Treatment Increases Cerebral Blood Flow in Asymptomatic APOE4 Females Determined by 3T MRI
Caitlin M Neher, Oleksandr Khegai, Jessica Overschmidt, Joanne Cassani, Xin Xing, Abeoseh Flemister, Stefan J Green, Mehmet Kurt, David Q Beversdorf, Feng Xu, John W Grinstead, Priti Balchandani, Talissa A Altes, Ai‐Ling Lin · 2025
Read Short‐term Sirolimus Treatment Increases Cerebral Blood Flow in Asymptomatic APOE4 Females Determined by 3T MRI by Caitlin M Neher, Oleksandr Khegai, Jessica Overschmidt, Joanne Cassani, Xin Xing, Abeoseh Flemister, Stefan J Green, Mehmet Kurt, David Q Beversdorf, Feng Xu, John W Grinstead, Priti Balchandani, Talissa A Altes, Ai‐Ling Lin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713815.txt.
Description
Caitlin Neher and a large team give a short course of a known immune drug to two healthy middle aged women who carry the top gene risk for Alzheimer's disease. Women with that gene face higher risk and show low brain blood flow decades before symptoms. Mouse work showed the drug restores flow.
Brain scans over weeks showed flow up in all zones checked, with cortex flow about a third higher after washout than at start. Deep memory zones rose by about a fifth to a quarter. No side effects or sugar shifts were seen. The tiny first human test backs larger trials.
Catalog record
| CREATOR | Caitlin M Neher, Oleksandr Khegai, Jessica Overschmidt, Joanne Cassani, Xin Xing, Abeoseh Flemister, Stefan J Green, Mehmet Kurt, David Q Beversdorf, Feng Xu, John W Grinstead, Priti Balchandani, Talissa A Altes, Ai‐Ling Lin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |