Pharmacodynamic effect of a new γ‐secretase modulator, RG6289, on CSF amyloid‐β peptides in a randomized Phase I study
Thomas Mueggler, Agnes Portron, Agnès Poirier, Annamarie Vogt, Tianxu Yang, Adnan Mohamed Abdi, Gwendlyn Kollmorgen, Norbert Wild, Cory Simmons, Kalbinder Mahil, Lothar Lindemann, Karlheinz Baumann, Taner Varda, Rosanna Tortelli, Irene Gerlach, Stefan Sturm · 2025
Read Pharmacodynamic effect of a new γ‐secretase modulator, RG6289, on CSF amyloid‐β peptides in a randomized Phase I study by Thomas Mueggler, Agnes Portron, Agnès Poirier, Annamarie Vogt, Tianxu Yang, Adnan Mohamed Abdi, Gwendlyn Kollmorgen, Norbert Wild, Cory Simmons, Kalbinder Mahil, Lothar Lindemann, Karlheinz Baumann, Taner Varda, Rosanna Tortelli, Irene Gerlach, Stefan Sturm (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713813.txt.
Description
Thomas Mueggler and co-authors reported this 2025 first-in-human study of a drug aimed at Alzheimer's disease. The drug tweaks an enzyme to cut output of long amyloid pieces that clump in the brain. At the same time, it raises shorter pieces thought to be harmless. Earlier drugs in this class stumbled, so careful early testing matters.
Healthy volunteers took single and rising daily doses, or dummy pills. Blood and spinal fluid were sampled for a day and a half after dosing. Twelve volunteers joined the spinal fluid part, nine on the drug and three on dummy pills. Readings swung widely, which the authors report plainly. The study maps how the drug moves amyloid balance in people, a step toward judging its promise.
Catalog record
| CREATOR | Thomas Mueggler, Agnes Portron, Agnès Poirier, Annamarie Vogt, Tianxu Yang, Adnan Mohamed Abdi, Gwendlyn Kollmorgen, Norbert Wild, Cory Simmons, Kalbinder Mahil, Lothar Lindemann, Karlheinz Baumann, Taner Varda, Rosanna Tortelli, Irene Gerlach, Stefan Sturm |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |