Voxel‐wise comparison of [18F]MK6240 and [18F]Flortaucipir for the diagnosis of individuals across the Alzheimer’s disease spectrum – the HEAD study
Bruna Bellaver, Guilherme Povala, Guilherme Bauer‐Negrini, Firoza Z Lussier, Livia Amaral, Pamela CL Ferreira, Val J Lowe, David N soleimani‐meigooni, Hwamee Oh, Dana Tudorascu, William J Jagust, William E Klunk, Belen Pascual, Brian A Gordon, Pedro Rosa‐Neto, Suzanne L Baker, Tharick Ali Pascoal · 2025
Read Voxel‐wise comparison of [18F]MK6240 and [18F]Flortaucipir for the diagnosis of individuals across the Alzheimer’s disease spectrum – the HEAD study by Bruna Bellaver, Guilherme Povala, Guilherme Bauer‐Negrini, Firoza Z Lussier, Livia Amaral, Pamela CL Ferreira, Val J Lowe, David N soleimani‐meigooni, Hwamee Oh, Dana Tudorascu, William J Jagust, William E Klunk, Belen Pascual, Brian A Gordon, Pedro Rosa‐Neto, Suzanne L Baker, Tharick Ali Pascoal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713812.txt.
Description
Two radioactive tracers both light up Alzheimer's tau tangles, and Bruna Bellaver and seventeen co-authors raced them head-to-head in a 2025 study of 132 people across the disease spectrum. Every participant received both scans, plus an amyloid scan to stage them.
Voxel-by-voxel accuracy maps showed the older tracer, flortaucipir, scoring numerically higher and wider than MK6240 at separating amyloid-positive from amyloid-negative healthy adults. The gap widened in mid-stage Braak regions, areas not expected to hold tau yet in such adults, which cuts both ways: sensitivity there may be signal or spillover. Groups ranged from healthy controls to dementia patients. The authors offer the maps as a chooser's guide: the tracers are not interchangeable, and which one wins depends on the stage and the question being asked.
Catalog record
| CREATOR | Bruna Bellaver, Guilherme Povala, Guilherme Bauer‐Negrini, Firoza Z Lussier, Livia Amaral, Pamela CL Ferreira, Val J Lowe, David N soleimani‐meigooni, Hwamee Oh, Dana Tudorascu, William J Jagust, William E Klunk, Belen Pascual, Brian A Gordon, Pedro Rosa‐Neto, Suzanne L Baker, Tharick Ali Pascoal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |