Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease
Hannah de Bruin, Colin Groot, ADNI, Henryk Barthel, Gérard N Bischof, Ronald Boellaard, Matthias Brendel, David M Cash, William Coath, Gregory S Day, Brad C Dickerson, Elena Doering, Alexander Drzezga, Christopher H van Dyck, Thilo van Eimeren, Wiesje M van der Flier, Carolyn Fredericks, Tim D Fryer · 2025
Read Connectivity as a universal predictor of tau spreading in typical and atypical Alzheimer’s disease by Hannah de Bruin, Colin Groot, ADNI, Henryk Barthel, Gérard N Bischof, Ronald Boellaard, Matthias Brendel, David M Cash, William Coath, Gregory S Day, Brad C Dickerson, Elena Doering, Alexander Drzezga, Christopher H van Dyck, Thilo van Eimeren, Wiesje M van der Flier, Carolyn Fredericks, Tim D Fryer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713789.txt.
Description
Hannah de Bruin and co-authors test whether brain links forecast where tau protein will spread in Alzheimer's disease. Their 2025 study spans more than three hundred people with the disease, most with rare forms that scar the brain in odd patterns. Tau scans were turned into chance scores for each of two hundred brain zones. Seed zones, where tau starts first, were marked so spread could be tracked against the brain's wiring.
Past work in the common form of the disease said tau moves from seed zones to linked zones. Rare forms test that claim hard, since their tau maps differ a lot. The authors set out to check if link-based spread holds across all forms alike, as their title claims.
Catalog record
| CREATOR | Hannah de Bruin, Colin Groot, ADNI, Henryk Barthel, Gérard N Bischof, Ronald Boellaard, Matthias Brendel, David M Cash, William Coath, Gregory S Day, Brad C Dickerson, Elena Doering, Alexander Drzezga, Christopher H van Dyck, Thilo van Eimeren, Wiesje M van der Flier, Carolyn Fredericks, Tim D Fryer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |