Reevaluating Melatonin’s Efficacy in Alzheimer’s Disease: A 20th‐Anniversary Updated Literature Review of Sleep Disturbances and Treatment Trials
Alisha Malhotra, Vrushabh Daga, Cliff Singer · 2025
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Description
Alisha Malhotra, Vrushabh Daga, and Cliff Singer update a twenty-year-old review on whether the sleep hormone melatonin helps sleep problems in the most common dementia of old age. Broken sleep in these patients is hard on both the patients and their families. The first large trial of the hormone for this problem was run two decades ago.
That trial tested two forms of the hormone, a slow-release low dose and a fast high dose, against a dummy pill in 157 patients. Wrist sensors showed no clear gain in measured sleep. Yet patient reports hinted that the slow-release form improved sleep quality. The new review weighs that trial against later work and asks whether timing and dose explain the mixed picture.
Catalog record
| CREATOR | Alisha Malhotra, Vrushabh Daga, Cliff Singer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |