Comparative analysis of clinical endpoint progression rates in sporadic Alzheimer’s disease and Down Syndrome‐related Alzheimer’s disease
Michael Rafii, Jessie Nicodemus‐Johnson, Suzanne B. Hendrix, Jonathan Wagg, Nicolas Fournier, Olivier Sol, Saskia Delpretti, Julien Rongere, Claude Rudaz‐Kohler, Marie Kosco‐Vilbois, Andrea Pfeifer, Johannes Streffer, Nuno Mendonca, Mitchell Wassom, Zayne Kirkham · 2025
Read Comparative analysis of clinical endpoint progression rates in sporadic Alzheimer’s disease and Down Syndrome‐related Alzheimer’s disease by Michael Rafii, Jessie Nicodemus‐Johnson, Suzanne B. Hendrix, Jonathan Wagg, Nicolas Fournier, Olivier Sol, Saskia Delpretti, Julien Rongere, Claude Rudaz‐Kohler, Marie Kosco‐Vilbois, Andrea Pfeifer, Johannes Streffer, Nuno Mendonca, Mitchell Wassom, Zayne Kirkham (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713750.txt.
Description
Michael Rafii and a large team of co-authors compare how Alzheimer's disease advances in two populations in a 2025 study. Trials for the common, sporadic form use a settled set of thinking and daily-life tests. Down syndrome carries its own high Alzheimer's risk, and its trials use adapted tests that probe the same skills. Whether the two score sets move at comparable speeds was unknown.
The team mapped the standard tests to their Down syndrome counterparts and mined two long-running cohorts, one for each form. They measured each test's rate of change relative to its own spread, a yardstick that lets unlike scales be compared. The comparison tells trial designers how large and how long a Down syndrome trial must be to see a drug's effect, and whether tools borrowed from sporadic Alzheimer's research can serve there.
Catalog record
| CREATOR | Michael Rafii, Jessie Nicodemus‐Johnson, Suzanne B. Hendrix, Jonathan Wagg, Nicolas Fournier, Olivier Sol, Saskia Delpretti, Julien Rongere, Claude Rudaz‐Kohler, Marie Kosco‐Vilbois, Andrea Pfeifer, Johannes Streffer, Nuno Mendonca, Mitchell Wassom, Zayne Kirkham |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |