The monoclonal antibody 17E1 selectively labels GFAP in 5xFAD mice
Christopher M. Norris, Susan D Kraner · 2025
Read The monoclonal antibody 17E1 selectively labels GFAP in 5xFAD mice by Christopher M. Norris, Susan D Kraner (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713748.txt.
Description
Christopher Norris and Susan Kraner characterize a lab antibody in mice in 2025. Their lab made antibodies that tag distressed support cells in the brain. One antibody was expected to bind a cut form of a key enzyme. To their surprise, the second antibody instead bound a support cell protein called GFAP.
Levels of that tagged protein run high in a mouse strain bred to model Alzheimer disease. Tests confirm the antibody labels the protein with care and skips close targets. A clean tag lets researchers track how support cells react as disease advances. The tool may reveal states of brain stress that other stains miss.
Catalog record
| CREATOR | Christopher M. Norris, Susan D Kraner |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |