Functional brain network organization supports cognitive function in patients with Alzheimer's Disease‐related pathological burden and brain atrophy
Ziwei Zhang, Micaela Chan, Ezra Winter‐Nelson, Gagan S Wig · 2025
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Description
Ziwei Zhang, Micaela Chan, Ezra Winter-Nelson, and Gagan Wig ask why some people stay sharp despite Alzheimer's damage in a 2025 paper. Scans can show plaques and shrinkage in people whose thinking still works well. The team tests whether the way brain networks are organized explains the gap. They focus on how separate or mixed the brain's systems look at rest.
Patients came from a national Alzheimer's imaging project. The team measured plaque load, brain shrinkage, and network layout for each person. People whose networks stayed well sorted kept better thinking scores at the same level of damage. Network layout, the study argues, belongs in models of the disease next to plaques and shrinkage.
Catalog record
| CREATOR | Ziwei Zhang, Micaela Chan, Ezra Winter‐Nelson, Gagan S Wig |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |