Spatial Pattern of Medial Temporal Lobe Cross‐Sectional and Longitudinal Structural Change in Cognitively Normal Individuals
Long Xie, Sandhitsu R Das, Yue Li, Laura EM Wisse, Emily McGrew, Xueying Lyu, Michael DiCalogero, Ujashi Shah, Ademola Ilesanmi, Amanda E Denning, Christopher D Brown, Jesse S Cohen, Lasya P Sreepada, Mengjin Dong, Niyousha Sadeghpour, Pulkit Khandelwal, Ranjit Ittyerah, Sadhana Ravikumar, Shokufeh · 2025
Read Spatial Pattern of Medial Temporal Lobe Cross‐Sectional and Longitudinal Structural Change in Cognitively Normal Individuals by Long Xie, Sandhitsu R Das, Yue Li, Laura EM Wisse, Emily McGrew, Xueying Lyu, Michael DiCalogero, Ujashi Shah, Ademola Ilesanmi, Amanda E Denning, Christopher D Brown, Jesse S Cohen, Lasya P Sreepada, Mengjin Dong, Niyousha Sadeghpour, Pulkit Khandelwal, Ranjit Ittyerah, Sadhana Ravikumar, Shokufeh (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713731.txt.
Description
Xie and co-authors pinpoint where the brain's memory center thins first in healthy people headed toward Alzheimer's disease. The medial temporal lobe hosts the earliest tau tangles, so the team mapped its thickness point by point in 3,036 cognitively normal adults. Brain scans were split by amyloid and tau status, and many participants had repeat scans over five years.
People with both amyloid and tau shrank fastest across the region. Even without amyloid, tau-positive people lost tissue faster in the entorhinal cortex and a neighboring strip, the very sites where tau starts. Change over time beat single snapshots, and shrinkage tracked tau load closely. These fine maps may yield early markers for trials of prevention.
Catalog record
| CREATOR | Long Xie, Sandhitsu R Das, Yue Li, Laura EM Wisse, Emily McGrew, Xueying Lyu, Michael DiCalogero, Ujashi Shah, Ademola Ilesanmi, Amanda E Denning, Christopher D Brown, Jesse S Cohen, Lasya P Sreepada, Mengjin Dong, Niyousha Sadeghpour, Pulkit Khandelwal, Ranjit Ittyerah, Sadhana Ravikumar, Shokufeh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |