Fosgonimeton attenuates amyloid‐β‐induced autophagic impairments in primary cortical neurons
Sherif M Reda, Wei Wu, Andrée‐Anne Berthiaume, Sharay E Setti, Robert W Taylor, Jewel L Johnston, Kevin J Church · 2025
Read Fosgonimeton attenuates amyloid‐β‐induced autophagic impairments in primary cortical neurons by Sherif M Reda, Wei Wu, Andrée‐Anne Berthiaume, Sharay E Setti, Robert W Taylor, Jewel L Johnston, Kevin J Church (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713728.txt.
Description
Sherif Reda and six co-authors test a candidate drug's effect on cell cleanup in Alzheimer's models in a 2025 paper. Brain cells rely on autophagy, a recycling system that clears toxic proteins. In Alzheimer's disease that system jams, leaving vesicles and aggregates to pile up and poison synapses.
The drug, fosgonimeton, boosts a growth factor pathway and had already shown protection in animal models, lowering a disease-linked protein. Here the team treated rat cortical neurons with its active form, then injured them with amyloid beta, the peptide that accumulates in the disease. Staining for neuronal and recycling markers let them watch the cleanup machinery. The paper reports the drug easing the amyloid-driven impairment of autophagy. Such mechanistic detail matters for a drug in development: it widens the case from symptom relief toward repairing a broken cellular process.
Catalog record
| CREATOR | Sherif M Reda, Wei Wu, Andrée‐Anne Berthiaume, Sharay E Setti, Robert W Taylor, Jewel L Johnston, Kevin J Church |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |