Alterations in protein conformation assessed by FTIR in EVs from an AD mimicking model
Margarida Vaz, Tânia Soares Martins, Odete da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques · 2025
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Description
Margarida Vaz and four co-authors use infrared light to watch Alzheimer's-related peptide reshape proteins in cell vesicles, in a 2025 study. Amyloid-beta, the peptide behind the disease's plaques, travels between cells inside extracellular vesicles and may seed further aggregation. The team treated mouse neuroblastoma cells with a short amyloid fragment for two days. Vesicles released into the medium were collected by ultracentrifugation and characterized.
Infrared spectroscopy then read the fold patterns of the proteins those vesicles carried. If the peptide changes its carriers' cargo, vesicles become part of the disease mechanism, not just messengers. That possibility matters for blood-based Alzheimer's tests, many of which already read vesicle contents for diagnostic signals.
Catalog record
| CREATOR | Margarida Vaz, Tânia Soares Martins, Odete da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |