Pharmacological Evaluation of Withanolide A for Anti‐Alzheimer’s Effects: Inhibition of Mitochondrial Permeability Transition Pore (mPTP)
Lalit Sharma, Yogesh Gupta · 2025
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Description
Lalit Sharma and Yogesh Gupta present a 2025 study on a plant compound against Alzheimer's disease. The disease brings memory loss, inflammation, and failing cell powerhouses. A pore in those powerhouses can swing open and damage neurons. The compound, from a famed Ayurvedic herb, has shown nerve-protective signs before. The team tested it in cell and mouse models of the disease.
Treated mice did better on maze and field tests of memory. Their brains held less of the toxic protein that marks the disease. The compound blocked the pore from opening, which kept cell voltage steady and cut harmful oxygen radicals. Energy output held up as well. Inflammation signals fell and growth factors rose. The authors back the compound as a candidate worth more study.
Catalog record
| CREATOR | Lalit Sharma, Yogesh Gupta |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |