Significant Relationship Between Worsening Sleep and Declining Brain Metabolism in APOE4+ Individuals
Anne E Hogue, Daniel H Silverman · 2025
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Description
Anne Hogue and Daniel Silverman link worsening sleep to falling brain energy use in a 2025 Alzheimer's study. The pair focus on people who carry the APOE4 gene form, a known risk factor. Earlier work by the team showed that people whose sleep got worse also lost memory and brain activity. One rear brain region that fades early in the disease stood out in that work.
The new study draws on more than 2,000 adults from over fifty sites in a national imaging project. Brain scans measured sugar use in forty-seven regions. Thinking tests tracked change over time. Carriers whose sleep worsened showed steeper drops in brain activity than non-carriers. The results tie sleep care to brain health for those at genetic risk.
Catalog record
| CREATOR | Anne E Hogue, Daniel H Silverman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |