PFTAIRE peptide degrading cyclin Y and ameliorating cognitive deficits in mouse models of Alzheimer’s Disease
Illhwan Cho, Minhae Cha, Hye Yun Kim, YoungSoo Kim · 2025
Read PFTAIRE peptide degrading cyclin Y and ameliorating cognitive deficits in mouse models of Alzheimer’s Disease by Illhwan Cho, Minhae Cha, Hye Yun Kim, YoungSoo Kim (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713712.txt.
Description
Illhwan Cho and three co-authors reported in 2025 a peptide that lowers a protein tied to memory loss in Alzheimer's disease. The protein, cyclin Y, blocks the strengthening of synapses that learning needs. Their peptide copies the part of a partner enzyme that grabs cyclin Y, luring it toward removal. It was built by solid-phase synthesis in the lab.
Tests showed the peptide binds its target, survives in blood and liver samples, and crosses into the brain. Injected into Alzheimer's model mice, it prevented memory failures on behavior tests. Brain protein scans showed ninety-three proteins shifted, with synapse release proteins up and stress proteins down. The authors present the peptide as a fresh route to Alzheimer's drugs.
Catalog record
| CREATOR | Illhwan Cho, Minhae Cha, Hye Yun Kim, YoungSoo Kim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |