Lower dorsal raphe nucleus activity reflects resilience to Aß‐related cognitive decline in preclinical Alzheimer’s disease individuals with mild depressive symptoms
Timothy Lawn, Prokopis C Prokopiou, Lukas Heinrich, Donovan Nancy, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi IL Jacobs · 2025
Read Lower dorsal raphe nucleus activity reflects resilience to Aß‐related cognitive decline in preclinical Alzheimer’s disease individuals with mild depressive symptoms by Timothy Lawn, Prokopis C Prokopiou, Lukas Heinrich, Donovan Nancy, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi IL Jacobs (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713594.txt.
Description
Timothy Lawn and co-authors ask, in 2025, whether quiet activity in a small brainstem hub marks resilience in early Alzheimer's disease. The hub helps control mood, thinking, and arousal, and it gathers disease proteins early. Ninety-two older adults from a Harvard aging study had brain scans while viewing new and familiar face-name pairs.
Participants also had scans for amyloid, a disease marker, and years of yearly thinking tests. The team linked the hub's response to novelty with later mental decline and mood changes, in people with mild depressive symptoms. Lower hub activity appeared to reflect resilience against amyloid-related decline. The result ties mood circuits to the disease's earliest stage.
Catalog record
| CREATOR | Timothy Lawn, Prokopis C Prokopiou, Lukas Heinrich, Donovan Nancy, Kathryn V Papp, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi IL Jacobs |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |