Brain Age Gap Correlates with 18F‐NAV‐4694 and 18F‐MK‐6240 Standardized Uptake Value Ratio
Reza Rajabli, Mahdie Soltaninejad, Neda Shafiee, Vladimir S Fonov, Nesrine Rahmouni, Stijn Servaes, Joseph Therriault, Serge Gauthier, Pedro Rosa‐Neto, D Louis Collins · 2025
Read Brain Age Gap Correlates with 18F‐NAV‐4694 and 18F‐MK‐6240 Standardized Uptake Value Ratio by Reza Rajabli, Mahdie Soltaninejad, Neda Shafiee, Vladimir S Fonov, Nesrine Rahmouni, Stijn Servaes, Joseph Therriault, Serge Gauthier, Pedro Rosa‐Neto, D Louis Collins (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713590.txt.
Description
Reza Rajabli and co-authors linked a brain-age score to protein scans in this 2025 study. A model trained on healthy brain scans can guess a person's age from one scan. The gap between that guess and true age may reflect brain harm in Alzheimer's disease.
The model was trained on about 40,000 scans from a large British data set and erred by less than a year. It was then applied to 245 scans from a second cohort with healthy adults and patients. The age gap tracked with scan measures of both amyloid and tau buildup, and more strongly than age alone. The authors present the gap as a cheap sign of disease load.
Catalog record
| CREATOR | Reza Rajabli, Mahdie Soltaninejad, Neda Shafiee, Vladimir S Fonov, Nesrine Rahmouni, Stijn Servaes, Joseph Therriault, Serge Gauthier, Pedro Rosa‐Neto, D Louis Collins |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |