Development and evaluation of clinically effective “APOE Genotyping PCR‐based assay kit” in Alzheimer’s Disease patients
Nozomi Kojima, Kozue Matsuda, Hikaru Hattori, Motonari Daitho, Tamao Tsukie, Ai Obinata, Akinori Miyashita, Takeshi Ikeuchi · 2025
Read Development and evaluation of clinically effective “APOE Genotyping PCR‐based assay kit” in Alzheimer’s Disease patients by Nozomi Kojima, Kozue Matsuda, Hikaru Hattori, Motonari Daitho, Tamao Tsukie, Ai Obinata, Akinori Miyashita, Takeshi Ikeuchi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11713565.txt.
Description
Kojima and co-authors describe a new gene test kit for Alzheimer's patients in this 2025 paper. The test reads the APOE gene, which affects the risk of a scan side effect from new antibody drugs. Doctors in the United States and Japan are urged to test the gene before treatment.
Older methods needed two tests to cover a hard-to-read stretch of the gene. The new kit sorts all six gene forms in a single test, thanks to careful design of its probes and heat settings. The team checked the kit on blood samples from patients. A fast, cheap, quality-checked test could lower costs and widen safe access to the new drugs.
Catalog record
| CREATOR | Nozomi Kojima, Kozue Matsuda, Hikaru Hattori, Motonari Daitho, Tamao Tsukie, Ai Obinata, Akinori Miyashita, Takeshi Ikeuchi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |